DETRIM - instructions for use

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For the treatment of domestic animals very often use the drug "Ditrim". Instructions for the use of this tool, indications and specific recommendations will be presented in this article.

Form of medicine for animals, its packaging, composition

Ditrim drug, the instruction of which is enclosed in cardboard packaging, is produced in the form of a light yellow sterile solution. It is packaged in glass hermetically sealed vials.

The composition of this medication includes sulfadimezin and trimethoprim, as well as additional ingredients.

Veterinary features

What is Dithrim solution? Instructions for use states that it is a very effective antibacterial agent with a broad spectrum of action.

Due to the active ingredients, this drug adversely affects the metabolism of acids, which are contained in microbial cells.

This tool is intended for the treatment and protection of domestic animals from various bacterial infections. It has a fairly low toxicity and completely eliminates resistance to the carriers of the disease.

Properties of the veterinary drug

How does the Dithrim solution work? The instruction states that trimethoprim and sulfadimezin, which are part of the drug, enhance the effects of each other. This happens due to the sequential effect of folic and n-aminobenzoic acid on metabolism in microbial cells. This drug is active against gram-negative microorganisms and gram-positive bacteria.

When administered intramuscularly, this means is resorbed and reaches a concentration peak after 3 hours. Ditrim retains its antibacterial properties throughout the day. In lactating animals, the drug is excreted in milk, and in the rest, in urine.

What diseases show “Dithrim” for animals? The instruction states that this remedy is prescribed for the treatment of bacterial infections, which are caused by microorganisms that are susceptible to it.

For different animals, the preparation in question is used for various reasons.

Small cattle - with infections of the respiratory tract, diarrhea, metritis, pasteurellosis, salmonellosis, eimeriosis and others.
Large cattle - with bronchopneumonia, paratyphoid fever, colibacteriosis, metritis, vibrious diarrhea, etc.
Horses - with bacterial pneumonia, septicopyemia, paratyphoid fever and diarrhea.
Pigs - with infections of the respiratory tract, metritis, bacterial dysentery, pasteurellosis, paratyphoid fever, colibacteriosis, MMA syndrome, eymerioze, malignant edema, isosporosis, and others.
Dogs - with pulmonary and intestinal infections, cystoisosporosis.
Rabbits - with amerioze and others.
Chickens, turkeys and ducks - with amerioze, etc.

Contraindications

In what cases it is impossible to use Dithrim solution? Instructions for rabbits and other animals states that a contraindication to the use of this agent is the increased sensitivity of livestock and birds to sulfanilamide drugs. It should also be noted that this drug is not used for pregnant females with kidney and liver diseases.

Medicament for animals "Dithrim": instructions for use

For chickens and other poultry, this drug is prescribed (for prophylactic purposes) at a dosage of 1 ml / l of water for 3 days. For treatment, the remedy in question is used in the same dose, but only for 5 days. The same goes for rabbits.

How else is Dithrim medication used? The instruction states that this drug is prescribed to farm animals in the form of intramuscular injections (for horses, it is better to administer intravenously). Its dosage is calculated as follows: 1 ml per 10 kg of weight, once a day.

For acute infections in the first three days, the drug is administered in a loading dose in the amount of 1 ml per 10 kg of weight twice a day every 12 hours.

Treatment with the considered drug is continued for two days after the disappearance of all clinical signs of the disease.

It is highly undesirable to continue therapy for more than 8 days. In the same place can not enter more than 20 ml of medication.

Side Effects and Overdose

Now you know how to use Dithrim medication. Instructions for use for chickens, rabbits and other livestock have been described above.

With proper use of this drug, side effects are not observed. In some animals, redness at the injection site and rapidly passing swelling may be observed during the use of this agent.

With an overdose of this drug is possible dysbacteriosis.

Special recommendations

Slaughter of animals for meat is permitted after 29 days after the last use of the drug.

In case of forced slaughter of livestock (earlier than the aforementioned period), meat should be given to feed for fur-bearing animals or for the production of bone meal.

Milk of lactating animals may not be used for food for 6 days after the last administration of the medication. Such a product can only be used after heat treatment as animal feed.

Release form, composition and packaging

Injection transparent, from yellow to brown-yellow.

Excipients: 2-pyrrolidone, benzyl alcohol, sodium thiosulfate, disodium EDTA, water d / i.

Packaged in 20, 50 and 100 ml in glass vials, sealed with rubber stoppers, reinforced with aluminum caps. Each consumer package is supplied with instructions for use.

Pharmacological (biological) properties and effects

Combined antibacterial drug.

Sulphadimezin and trimethoprim as part of the drug have a synergistic effect, successively affecting the metabolism of n-aminobenzoic and folic acids in the microbial cell, which provides a wide range of bacteriostatic activities against gram-positive and gram-negative microorganisms, including: Escherichia coli, Bacillus anthracis, Bordetella spp., Salmonella spp., Proteus spp., Campylobacter spp., Haemophilus spp., Enterobacter spp., Pasteurella spp., Staphylococcus spp., Shigella spp., Vibrio sf. Klebsiella spp., Corynebacterium spp.

After parenteral administration of the drug, the active substances are well absorbed into the blood and penetrate into most organs and tissues of the body. The maximum concentration in the blood is reached in 2-3 hours and remains in therapeutic concentrations for 18-24 hours after administration. The highest concentrations of active ingredients are reached in the lungs, liver and kidneys. The drug is removed from the body of animals, mainly in the urine and in small quantities with bile, in lactating animals - partly with milk.

Ditrim ® according to the degree of impact on the body belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76).

Application procedure

Ditrim ® is injected intramuscularly in the neck (horses - in / in) 1 time / day in a dose of 1 ml per 10 kg of animal weight. With severe disease the first 2-3 days, the drug is used 2 times / day with an interval of 12 hours at the same dose.

In connection with a possible painful reaction, the drug should not be administered in the same place. cattle, pigs and horses - more than 10 ml piglets and dogs - more than 5 ml.

The duration of treatment is 3-7 days.

Features of the action at the first use of the drug and the cancellation was not detected.

When you skip one or more doses of the drug, you must resume use in the prescribed dose and in the same way.

Side effects

When used in recommended doses in accordance with the instructions, side effects and complications, as a rule, are not observed. In some animals, redness and swelling may occur at the injection site, which spontaneously disappear and do not require treatment.

With overdose or exceeding the duration of the recommended course of treatment possible violations of the kidneys and gastrointestinal tract (dysbiosis). In this case, it is necessary to discontinue the use of the drug and prescribe a symptomatic treatment (vitamins and probiotics).

Special instructions and measures for personal prevention

Ditrim ® should not be used simultaneously with n-aminobenzoic acid preparations (novocaine, procaine, anesthesin, benzocaine), as well as mixed in the same syringe with other drugs.

Slaughter of animals for meat is allowed no earlier than 28 days after the last use of the drug. Meat of animals, forcedly killed before the expiration of the specified periods, can be used for feeding fur-bearing animals. Milk of dairy animals should not be used for food for 5 days after the end of the use of the drug Ditrim ®. Such milk can be used after heat treatment for feeding animals.

Personal preventive measures

During the work with the drug Ditrim ® it is necessary to follow the general rules of personal hygiene and safety measures provided during the work with medicines. During work, it is forbidden to drink, smoke and eat. At the end of the work hands should be washed with warm water and soap.

People with hypersensitivity to the drug should avoid direct contact with Ditrim ®. If the product comes into contact with the skin or mucous membranes of the eyes, they should be washed with plenty of tap water. In the event of an allergic reaction or in case of accidental ingestion of the drug in the human body, you should immediately contact a medical institution (you should have the instructions for use of the drug or a label with you).

Empty vials and bottles of the drug should not be used for domestic purposes, they should be disposed of with household waste.

Complex antibacterial drug, the components of which enhance the action of each other

Synergism of components prevents the development of resistance

Double force of antimicrobial action

Suitable for rotation with most modern antibiotics.

Comprehensive antibacterial drug for the treatment of animals, occupying a leading position in the Russian Federation and the CIS among the drugs based on trimethoprim and sulfadimezin.

The drug in appearance is a sterile solution of a light yellow color.

Dithrim is packaged in 20, 50 and 100 ml packaged in hermetically sealed glass vials.

Sulfadimine and trimethoprim, which are part of Ditrim, enhance the action of each other by consistently affecting the metabolism of n-aminobenzoic and folic acids in the microbial cell, providing a wide range of antibacterial action. Ditrim is active against gram-positive and gram-negative microorganisms. The spectrum of action of the drug covers E. coli, Clostridium spp., Salmonella spp., Proteus spp., Bacillus anthracis, Pasteurella spp., Haemophilus spp., Vibrio spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Cyrus spp., Streptococcus spp., Shigella spp. , Klebsiella spp., Fusobacterium spp., Bordetella spp., Brucella spp., Campylobacter spp., Enterobacter spp.

With intramuscular administration, Ditrim is resorbed and reaches a maximum concentration 2-3 hours after the injection. Antibacterial action lasts for 18-24 hours. The highest concentrations of active ingredients are reached in the lungs, liver and kidneys. The drug is excreted from the body, mainly with urine, in lactating animals, partly with milk.

Farm animals Ditrim is administered intramuscularly to the neck once a day at a dose of 1 ml per 10 kg of animal weight (horses intravenously). In severe cases of the disease, the first 2-3 days, the drug is administered twice a day with an interval of 12 hours at the same dose.

The course of treatment is 3-7 days. In connection with a possible painful reaction, more than 10 ml of the preparation, piglets and dogs - more than 5 ml should not be injected into one place of cattle, pigs and horses.

At use in the recommended doses of by-effects and complications, as a rule, it is not observed.

Slaughter of animals for meat is allowed not earlier than 28 days after the last use of Dietrim. The meat of animals that were involuntarily killed before the expiration of the specified period can be used as feed for fur-bearing animals.

Milk milk animals can be used for nutritional purposes within 5 days after the last injection of the drug. Milk obtained during the treatment and for 5 days after the last injection of the drug can be used after boiling the animal feed.

Drug properties

The active elements that make up the drug increase the effectiveness of each other through the action of folic and aminobenzoic acid on the metabolism in the microbial cell. Thus, there is a provision of a broad spectrum of antibacterial action. Drug fights with gram-negative and gram-positive microorganisms.

Ditrim is resorbed and reaches maximum concentration after three hours with intramuscular administration. During the day, the antibacterial effect remains. The drug is excreted through the urine or with milk.

The drug Ditrim has the following advantages:

eliminates the emergence of resistance in pathogens,
toxicity is low
It is a powerful medicine for the treatment of bacterial infections.

Indications for use

Ditrim is indicated for animals with bacterial infection.. The indications for using the medication are as follows:

with eymerioze drug Ditrim is shown to birds, rabbits, small cattle,
intestinal diseases and infections in the lungs of dogs and rabbits,
in pneumonia, intestinal disorders and paratyphoid, the preparation is prescribed to cattle,
paratyphoid, respiratory diseases, isoporosis in pigs,
with diarrhea, septicopyemia, and pneumonia, medication is prescribed for horses.

Dosing and Administration

Ditrim injections prescribed various pet households. 1 ml of the solution goes to 10 kg of weight. It is made once a day. Intravenous recommended injections of medicine to horses. For serious infectious diseases, the highest dose is prescribed in the first two days. It is calculated in the same way. The animal is injected twice daily. The break must be at least eleven hours. After the serious symptoms are gone, the drug is withdrawn for several days. The treatment is not carried out for longer than a week. It is necessary to choose different places for injections, since no more than twenty ml of Ditrim's medicine is allowed to be injected into one place.

Have Ditrima for rabbits instructions for use as follows: in the prevention of diseases take one milliliter of the drug and a liter of water. This drink is served for three days. For diseases, animals prepare a similar solution and dispense for three days, then take a break and again three days of treatment.

In the prevention of diseases in birds One milliliter of the drug is diluted in a liter of water. For three days, the animal should consume this solution. When diseases are prepared the same solution as in rabbits. The medicine for ducks is prepared differently: in the course of prophylaxis, two milliliters of the drug are taken to a liter of water and given to the bird for three days. In the treatment of diseases per milliliter of Dietrim per liter of water. The regimen is similar to the treatment of rabbits.

When canceling the use of the drug Ditrim and its first use, no signs of action were found. In the case of skipping medication is required to restore the use of the previous scheme in the same dosage. The use of the drug in the syringe with procaine and benzocaine is prohibited. Убой животного на мясо разрешён через месяц, а употребление молочных продуктов через неделю после приёма лекарственного средства Дитрим.

Передозировка

Бывает, что на дерме животного возникает припухлость и небольшое покраснение в месте инъекции. Такие симптомы исчезают самостоятельно без дополнительного вмешательства. Строго запрещены нарушения дозировок лекарства, а также его долгое использование. Это связано с негативным воздействием на функционирование почек, желудка и кишечника.

If the dosage was calculated correctly and the instructions were followed, no negative complications were identified. If the animal manifested a negative reaction to the drug, then its use should be canceled and consult with a veterinarian.

Drug storage and safety measures

Dithrim is stored in a dark, dry room with a temperature of up to 24 degrees Celsius. If the medicine is kept in these conditions, then its shelf life is two years. When applying it, you must follow the rules of safety and personal hygiene.

Direct contact with the drug should be avoided by people. with sensitivity to its components. It is necessary to rinse with cold water the mucous membranes or the skin when it gets on them. If allergies occur, consult a doctor. Empty jars of the medicinal product are not allowed to be used in everyday life, as they must be disposed of.

It is a non-toxic drug that can easily withstand bacterial infections, while not causing sustainability. Proper use of the drug Ditrim will not bring negative consequences. The drug has successfully established itself in the treatment of diseases of rabbits and birds.

Dietrim drug and its use in veterinary medicine

In traditional veterinary medicine, the drug "Dithrim" is prescribed to animals for the treatment of viral, bacterial diseases of various genesis, etiology. This is a complex systemic antibacterial medicine prepared on the basis of sulfadimezin and trimethoprim, as well as other auxiliary components. It has a pronounced broad antimicrobial action.

Description of veterinary preparation

Ditrim for animals belongs to the group of effective, complex antibacterial drugs. Available in the form of a sterile injectable alkaline solution of light yellow, light brown color, as well as in the form of a suspension for oral administration.

Packed in vials of dark neutral glass 10, 20, 50, 100 ml, which are hermetically sealed with aluminum lids and packed in cardboard boxes with instructions for use. Packages, bottles should be labeled "sterile", "For animals."

The complex antibacterial drug is based on a unique balanced formula. All components that are part of Dietrim, reinforce each other. Apply to birds, warm-blooded animals, fur animals.

Ditrim for birds, animals produced in the form of an injection solution

In addition to the main active ingredients (sulfadimesin 20%, trimethoprim 4%), the following substances are included in the composition of the pharmacological agent: benzyl alcohol, pyrrolidone-2, sodium thiosulfite, disodium salt, lead for injection.

Dithrin belongs to the group of low toxic, safe drugs for animals (4th class of danger). At observance of therapeutic doses, it does not cause carcinogenic, sensitizing, teratogenic, mutagenic, embryotoxic effects.

Store the drug, according to the instructions, protected from UV radiation, dry, dark places away from children, food, in a hermetically sealed form at a temperature of from 0 to 22 ° C.

Properties and pharmacodynamics

The drug Ditrim, in addition to a broad antibacterial action, has a pronounced synergistic effect. Does not cause the stability of pathogenic microflora, the simplest. The active ingredients consistently enhance the action of each other, providing a prolonged effect after oral administration of the veterinary drug.

Ditrim is effective against most gram-positive, gram-negative bacteria, microorganisms. It has a negative effect on Escherichia coli, Pasteurella, Klebsiella, Strepto, Staphylococcus, Brucellosis pathogens.

The mechanism of action of the active ingredients is based on the effect on the metabolism of n-aminobenzoic, folic acid in microbial cell structures, thereby providing a wide range of antibacterial action.

When administered intramuscularly, the drug is resorbed, evenly distributed in tissues, organs. The maximum concentration of the agent in the bloodstream is achieved 2–3 hours after administration. The antibacterial effect lasts for 22-24 hours.

Excreted from the body of animals mainly in the form of metabolites with urine, bile, less often - with feces. In lactating (lactating) females - with colostrum, milk.

Instructions for use in veterinary medicine

For various groups of animals, if Ditrim is injected, the dosage is calculated on the basis of 1 ml of the drug per 10 kg of weight. Injection put once a day. Enter intramuscularly. Horses can enter the veterinary drug intravenously. For rabbits, poultry, the drug is diluted in drinking water, added to the drinkers.

For fur animals, for the purpose of prophylaxis, it is enough to dilute 1 ml of the veterinary preparation in a liter of water. Feed the animals for three days. In the treatment of Ditrim give 5 days, then make a break for 3 days, after which the treatment is carried out again for 2 days.
For chickens, turkeys, ducks 1 ml of the drug is diluted in a liter of water. They are fed for 3-5 days.

For birds Ditrim diluted in water, poured into water bowls

In acute bacterial infections, viral diseases Ditrim is administered 2 times a day with an interval of 12-13 hours. Treatment is carried out until complete recovery of the animals. At the same time, it is undesirable for the course to exceed 7–8 days.

Instructions for use of the drug Ditrim in veterinary medicine

In veterinary medicine, Ditrim is prescribed for animals with infectious diseases caused by bacteria. This drug is antibacterial. He won a leading position in the CIS countries and the Russian Federation among drugs based on sulfadimezin and trimethoprim.

The drug is produced in the form of a light yellow sterile substance of 20, 50 or 100 ml in a glass jar.

The drug Ditrim has the following advantages:

eliminates the emergence of resistance in pathogens,
toxicity is low
It is a powerful medicine for the treatment of bacterial infections.

Use of the drug Ditrim in veterinary medicine for animals and birds

Preparations for animals and birds

In classical veterinary medicine, Dithrim medication is prescribed for the treatment of viral and bacterial diseases. This is a systematic complex antibacterial drug based on sulfadimezin and trimethoprim. The drug has an extensive antimicrobial effect. The drug is prescribed to birds and animals both for the purposes of prevention and for the required treatment.

Ditrim for animals belongs to the group of effective, antibacterial pharmaceutical agents.

Available in the form of a sterile injective alkaline solution of a pale yellow, pale brown color, and, moreover, in the form of a suspension for oral use.

Packed in bottles of black neutral glass of 10, 20, 50, 100 milliliters, covered with lids and packed in cardboard boxes along with instructions for use. Packages, vials should have the text "Sterile", "For animals".

Complex antibacterial drug based on the original balanced formula. All substances that are part of Dietrim, enhance the effect of each other. Use for birds, warm-blooded animals, fur animals.

In addition to the key functioning parts (sulfadimezin 20%, trimethoprim 4%), the following substances are included in the pharmacological agent: benzyl ethanol, pyrrolidone-2, sodium thiosulfite, disodium salt, water for injection.

Ditrin belongs to the team of low toxic, non-hazardous medicines for animals (4th class of danger). When following a therapeutic dose does not show a carcinogenic, sensitizing, teratogenic, mutagenic, embryotoxic effect.

Store the drug, according to the instructions, protected from UV radiation, dry, dark areas away from children, food, tightly closed at a temperature of 0 to 22 ° C.

The drug Ditrim has an extensive antibacterial effect. Effective against many gram-positive, gram-negative microorganisms, bacteria. It has a negative effect on E. coli, pasteurella, Klebsiella, streptococcus, staphylococcus, brucellosis pathogens.

The mechanism of action of the active ingredients is based on the effect on the metabolism of n-aminobenzoic, folic acid in microorganism cellular textures, thereby providing an extensive range of antibacterial effects.

With intramuscular injection, the drug is resorbed, equally distributed in tissues, organs. The highest concentration of the agent in the bloodstream is achieved in 2–3 minutes after administration. Antibacterial result lasts for 22-24 hours.

Excreted from the body of animals with urine, bile, at least - with feces. In lactating (lactating) females - with colostrum, milk.

Ditrim for birds, animals designed for use in the treatment of enterobacterial, viral diseases, infections. The drug is prescribed:

cattle, goats, sheep with diarrhea, paratyphoid fever, colibacteriosis, metritis, pasteurellosis, viral diseases of the respiratory tract,
dogs for the treatment of intestinal, pulmonary infections,
horses with bronchopneumonia, paratyphoid, foals with diarrhea,
pigs with isoporosis, colibacteriosis, lung infections, malignant edema,
rabbits at eymerioze,
poultry at eymerioze.

For any type of animal dosing, the duration of healing therapy is chosen individually.

So, consider the instructions for use. For different groups of animals (cats, piglets, calves), if Ditrim is injected, the dosage is calculated at the rate of 1 ml of the substance per 10 kilogram of weight.

Injection put once a day. Enter intramuscularly. Horses may be administered intravenously. For rabbits, poultry, including broiler chickens, the powder is diluted in drinking water, added to the drinkers.

For fur-bearing animals for the purpose of prophylaxis, it will be enough to dilute 1 ml of veterinary preparation in a liter of water. Feed the animals for 3 days. In the treatment of Ditrim give 5 days, then make a break for 3 days, after which the treatment is again carried out for 2 days. For chickens, turkeys, ducks, 1 ml of the substance is diluted in a liter of water. 3-5 days are drunk.

For acute enterobacterial infections, viral diseases Dithrim is administered 2 times a day with an interval of 12-13 hours. Treatment is performed until the animals are completely cured. At the same time, it is undesirable that the course exceeds 7–8 days.

When following advised dosages of secondary symptoms are not observed. At the injection site, slight swelling, redness can be seen. Similar signs pass on the 2-3rd day without therapy.

In animals during the period or immediately after treatment in the rarest of cases, there is a violation of digestion. Allergic reactions, depressed state, lethargy are likely. In case of overdose, with hypersensitivity to the components of the drug, the kidneys and the gastrointestinal tract are disturbed.

Detrim in veterinary medicine is contraindicated in animals with personal intolerance to parts of a pharmaceutical agent, hypersensitivity to sulfanilamides, and prolonged pathologies of the kidneys and liver. Not advised to use pregnant, lactating females.

Slaughtering animals for meat is possible only after 28–30 days after completion of the treatment course. Milk may be used in food 5 days after treatment. When forced slaughter meat is used for the production of meat and bone meal.

Ditrim for rabbits: instructions for use in veterinary medicine

In the veterinary market there are many drugs specifically designed for the treatment of diseases caused by bacteria. In veterinary medicine, the drug Ditrim has firmly taken its place, experts call it the leader in the fight against infectious diseases.

Ditrim is widely known for its antibacterial properties. This is an injection, which consists of two main components:

Auxiliary components,

Pyrrolidone.
Benzyl alcohol.
Sodium thiosulfate.
Water for injections.
EDTA salt disodium.

Sulfadimizin considered to be a powerful antimicrobial agent. Based on this substance, modern veterinarians make up medicines designed to protect and cure the infection.

This substance is well absorbed by the animal, quickly absorbed and slowly excreted from the body.

Thanks to it has "Cumulative" effect, accumulates in the blood of an infected animal and has a negative impact on harmful microorganisms.

Trimethoprim part of many drugs. This antimicrobial substance, which is absorbed and evenly distributed throughout the body after 2−3 hours. Trimethoprim blocks the development and reproduction of harmful microorganisms, thereby preventing the spread of infection throughout the body.

Ditrim drug is considered to be a broad-spectrum drug.

The medicament is produced in glass containers, a bottle of dark glass is securely and hermetically sealed. The solution is light yellow, sterile. The volume of the bottle is 20, 50 and 100 ml.

Store the drug is recommended in a dry, cool place, away from children and animals. Shelf life is 24 months.

Ditrim for rabbits: instructions for use

Rabbits and poultry, such as ducks, chickens and turkeys, are given the drug if they are suspected of having eimeriosis.

Injections for rabbits and poultry It is extremely difficult to do, so the medicine is diluted in water and given to a sick animal as a drink.

The drug is diluted in water (1 ml per 1 liter of water). Drinking rabbits give for 5 days or 3 days of treatment, then a break of 2 days, then again 3 days of treatment.

Precautionary measures

When working with the drug to a person it is necessary to follow generally accepted rules. Personal hygiene products: gloves and a mask are welcome. In the process of work it is not recommended to drink, eat and smoke.

It is necessary to protect eyes, mucous membranes of the mouth and nasal cavity. If the medication gets into the eyes, the affected area should be washed with plenty of running water.

If the drug gets into the oral cavity, you should seek medical help, as poisoning is possible.

It should be remembered that the slaughter of an animal after the use of an antibacterial drug is possible after 30 days. If slaughter is forced, then meat cannot be eaten.

Advantages and disadvantages

The drug has many advantages. According to consumer reviews, the advantages include:

wide range of action of the drug,
acceptable price,
powerful therapeutic and prophylactic action,
low toxicity
quite long shelf life

The drug has only one minus.: the possibility of an allergic reaction. Therefore, before use, experts recommend making a test injection. If swelling and redness are not observed, then the animal has no intolerance to the drug.

Dithrim: instructions for use in veterinary medicine, price, readings | Buy Ditrim for animals, NITA-FARM

| Buy Ditrim for animals, NITA-FARM

Description
Comprehensive antibacterial drug for the treatment of animals, occupying a leading position in the Russian Federation and the CIS among the preparations based on trimethoprim and sulfadimezina. The preparation in appearance is a sterile solution of a light yellow color. Dytrim is packaged in hermetically sealed glass vials. .
Composition
Pharmacological properties
Sulfadimine and trimethoprim, which are part of Ditrim, enhance the action of each other by consistently affecting the metabolism of n-aminobenzoic and folic acids in the microbial cell, providing a wide range of antibacterial action. Ditrim is active against gram-positive and gram-negative microorganisms. The spectrum of action of the drug covers E. coli, Clostridium spp., Salmonella spp., Proteus spp., Bacillus anthracis, Pasteurella spp., Haemophilus spp., Vibrio spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Cyrus spp., Streptococcus spp., Shigella spp. , Klebsiella spp., Fusobacterium spp., Bordetella spp., Brucella spp., Campylobacter spp., Enterobacter spp. When administered intramuscularly, Dithrim is resorbed and reaches a maximum concentration 2-3 hours after injection. Antibacterial action lasts for 18-24 hours. The highest concentrations of active ingredients are reached in the lungs, liver and kidneys. The drug is excreted from the body, mainly with urine, in lactating animals, partly with milk.
Indications for use
Сульфадимезин и триметоприм, входящие в состав Дитрима, усиливают действие друг друга путем последовательного воздействия на метаболизм n-аминобензойной и фолиевой кислот в микробной клетке, обеспечивая широкий спектр антибактериального действия. Дитрим активен против грамположительных и грамотрицательных микроорганизмов. Спектр действия препарата охватывает E.coli, Clostridium spp., Salmonella spp., Proteus spp., Bacillus anthracis, Pasteurella spp., Haemophilus spp., Vibrio spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Corynebacterium spp., Klebsiella spp., Fusobacterium spp., Bordetella spp., Brucella spp., Campylobacter spp., Enterobacter spp.При внутримышечном введении Дитрим резорбируется и достигает максимальной концентрации через 2-3 часа после инъекции. Антибактериальное действие сохраняется в течение 18-24 часов. The highest concentrations of active ingredients are reached in the lungs, liver and kidneys. The drug is excreted from the body, mainly with urine, in lactating animals, partly with milk.
Farm animals Ditrim is administered intramuscularly to the neck once a day at a dose of 1 ml per 10 kg of animal weight (horses intravenously). In severe cases of the disease, the first 2-3 days, the drug is administered twice a day with an interval of 12 hours at the same dose. The treatment course is 3-7 days. In connection with a possible painful reaction, more than 10 ml of the preparation, pigs and dogs - more than 5 ml should not be injected into one place of cattle, pigs and horses. As a rule, no side effects and complications are used at recommended doses.
Dosage and method of use
Farm animals Ditrim is administered intramuscularly to the neck once a day at a dose of 1 ml per 10 kg of animal weight (horses intravenously). In severe cases of the disease, the first 2-3 days, the drug is administered twice a day with an interval of 12 hours at the same dose. The treatment course is 3-7 days. In connection with a possible painful reaction, more than 10 ml of the preparation, pigs and dogs - more than 5 ml should not be injected into one place of cattle, pigs and horses. As a rule, no side effects and complications are used at recommended doses.
Restrictions
Slaughter of animals for meat is allowed not earlier than 28 days after the last use of Dietrim. Meat of animals that were forced killed before the expiration of the specified period, can be used in the feed for fur-bearing animals. Milk animals can be used for food for 5 days after the last injection of the preparation. Milk obtained during the treatment and for 5 days after the last injection of the drug can be used after boiling the animal feed.
Publications
Therapeutic efficacy of DietrimaComparative assessment of Cefotaxime and Dietrim in the treatment of calves with bronchopneumonia
Treatment regimens

Ditrim powder 500ml For calves, foals, lambs, piglets and dogs for the treatment of bacterial infections of the respiratory, gastrointestinal and genitourinary systems caused by susceptible microorganisms to buy

Sale: Ditrim powder 500ml For calves, foals, lambs, piglets and dogs for the treatment of bacterial infections of the respiratory organs, gastrointestinal tract and urinary system, caused by microorganisms sensitive to the drug. Price: from 500 rubles.

A complex antibacterial drug containing in 1 g as an active ingredient 100 mg of sulfadimezin and 20 mg of trimethoprim, as well as auxiliary components calcium stearate and lactose (or sucrose).

It is a granular powder of white to grayish-white color, when mixed with water, forms a suspension. Packed up in 500g polymer banks.

Pharmacological properties: Sulfadimezin and trimethoprim, which are part of the drug, show synergism of action, i.e., they reinforce the action of each other by consistently affecting the metabolism of n-aminobenzoic and folic acids in the microbial cell.

The interaction of these components contributes to the expansion of the antibacterial spectrum of the drug. The spectrum of action of the drug covers gram-positive and gram-negative microorganisms, including E. coli, Clostridium spp., Salmonella spp., Proteus spp., Bacillus anthracis, Pasteurella spp., Haemophilus spp.

, Vibrio spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Corynebacterium spp., Klebsiella spp., Fusobacterium spp., Bordetella spp., Brucella spp.).

After oral administration, dithrim powder is rapidly absorbed in the gastrointestinal tract and penetrates into the organs and tissues of the animal’s body, reaching a maximum concentration 2–3 hours after administration. Antibacterial action is maintained throughout the day.

Ditrim powder according to the degree of impact on the organism of warm-blooded animals belongs to moderately hazardous substances, in the recommended doses it does not have a sensitizing, embryotoxic, teratogenic and mutagenic action. Excreted from the body mainly with urine and feces.

Indications: Assign calves, foals, lambs, piglets and dogs for the treatment of bacterial infections of the respiratory system, gastrointestinal tract and urinary system, caused by microorganisms sensitive to the drug.

Doses and method of use: Dithrim powder is mixed with food or suspended in a small amount of water, milk or its substitute and administered to animals orally individually once a day at the rate of: on the first day of treatment - 5 g per 10 kg of animal weight, on subsequent days of treatment - 2.5 g per 10 kg of animal weight. The course of treatment is 3 to 5 days. In severe cases of the disease, treatment is continued for up to 7 days.

Side effects: With proper use and dosage, side effects are usually not observed. With increased individual sensitivity of the animal to the components of the drug and the appearance of side effects (refusal of food, vomiting), the use of ditrim is stopped.

Contraindications: Hypersensitivity to sulfa drugs, hematopoietic dysfunction, liver and kidney diseases. It is not recommended to use the drug during pregnancy. During treatment with ditrim, the use of n-aminobenzoic acid preparations - novocaine (procain), anesthesin (benzocaine) is prohibited.

Special instructions: Slaughter of animals for meat after applying Ditrim powder is allowed after 7 days. In the case of the forced slaughter of animals of a predetermined period, the meat may be used as food for animals or for the production of meat and bone meal.

All work with the drug should be carried out in compliance with the rules of personal hygiene and safety, provided when working with veterinary drugs. In case of accidental contact with the drug on the skin or mucous membranes, it is necessary to immediately remove it with a swab and wash off with plenty of water.

At the end of the work hands should be washed with warm water and soap, wash and dry the gloves. Do not use empty vials from under the drug for food purposes.

Storage conditions: With the precaution of the list B. In a dry, protected from direct sunlight and out of the reach of children and animals at a temperature of from 0 to 25 ° C. Shelf life - 2 years.

Moscow region, Balashikha city, Zvezdnaya street, house 7, building 1 Telephone / fax: 8 (495) 542-70-54, 542-70-55

E-mail: [email protected] - on ordering, availability of goods

Veterinary Ditrim: instructions for use of the drug

In veterinary medicine, animals are prescribed ditrim for the treatment of infections caused by various bacterial microorganisms.

Ditrim is a complex antibacterial drug for the treatment of animals, occupying a leading position in the Russian Federation and the CIS among drugs based on trimethoprim and sulfadimezin.

Available in the form of a sterile solution of light yellow color, packaged in 20, 50 and 100 ml in hermetically sealed glass vials.

5 Contraindications
6 Features
7 Storage conditions and security measures

Description and composition of the drug

Ditrim drug consists of 20% sulfadimezin, 4% trimetaprim and additional components.

1 ml of the drug consists of the following substances:

40 mg of trimetaprim,
200 mg of sulfadimezin,
other substances (benzyl alcohol, 1 ml of water for injection, pyrrolidin-2, sodium thiosulfate, disodium salt - EDTA).

Dithrim is an alkaline solution of a light yellow color. The release form of the drug - in the form of a solution of high sterilitypackaged in sealed glass bottles with various volumes from 20 to 500 ml.

On the label of the initial packaging there is detailed information on the preparation: date of manufacture, serial number of production, shelf life of ditrim, name and composition of the preparation. And also must be inscribed on the bottles: for animals and sterile.

There are instructions for use, methods of administration of animals and storage conditions of the drug.

The effect of the injection is based on a broad spectrum antibacterial effect. The drug can be administered to animals in an oral way, as well as in the form of injections.

Ditrim properties

The impact of the drug extends to the following bacteria:

Clostridium spp,
Corrynebacterium spp,
E. coli
Streptossusus spp,
Stafylosossus spp,
Fusobacterium spp,
Salmónella spp
Bordetella spp,
Pasteurella spp. and some others.

Used in Ditrim substances enhance the actions of other components, affecting the metabolism of various acids in the infected cell, providing an antibacterial effect of extended action. The drug is very active in many microorganisms.

The maximum content of ditrim in the blood is felt after 2-3 hours after intramuscular injection. The effect of the drug continues for two days. In lactating animals, the drug is partially excreted in milk. All the rest - with urine.

Indications for use of the drug

Ditrim is discharged to animals that have caught infections of a bacterial nature.

Dogs with lung infections and intestinal diseases, as well as with cystoisosporosis.
Chickens, ducks and turkeys with disease Eimeriosis.
Cattle for diarrhea, pneumonia, paratyphoid fever, colibacillosis and some other diseases.
Small cattle with diarrhea, salmonellosis, metritis, pasteurellosis, infections of the respiratory system, eimeriosis.
For horses, the drug is prescribed for pneumonia of a bacterial nature, diarrhea in young foals, paratyphoid fever, and septicopyemia.
Pigs with malignant edema, eimeriosis, isoporosis, paratyphoid fever, respiratory diseases, colibacillosis and others
Rabbit Dithrim is prescribed for Ameriosis.

Method of application and calculation of dosage

Various cattle, as well as other animals of agriculture, dithrim is prescribed in the form of injections. 10 ml of animal weight is calculated 1 ml of solution. The injection is made once a day. Horses drug is recommended to be administered intravenously.

In acute infectious diseases take the highest dose of ditrim in the initial 2-3 days. The dose is calculated similarly: for 10 kg of mass - 1 ml of solution. The injection is placed 2 times a day with a break of 12 hours.

After the disappearance of the bright symptoms of the disease Ditrim displays another 2 days. Treatment is not recommended for a long time (longer than a week).

It is necessary to use different places for injection, in one and the same place you can enter no more than 20 ml of ditrim.

For poultry and rabbits prepare a fresh solution for drinking:

For the prevention of disease in rabbits used a liter of water with 1 ml of the drug. Drinking is offered 3 days. For the treatment of an animal, a solution is prepared in the same dosage, but is given to rabbits for 3 days in a row, 2 days off, 3 days of treatment.
For the prevention of the health of chickens and turkeys prepare a liter of drink with 1 ml of ditrim. Drinking is also offered to an animal for 3 days. A similar solution is prepared for the treatment of various diseases and is given to an animal in the same way as for rabbits.
To ducks, the solution is prepared in the following proportions: 2 ml of ditrim and 1 l of water for prophylaxis (the course is 3 days) and 1 ml of ditrim and 1 l of water for treatment - the course is similar to the courses of other animals.

In some cases, redness may appear on the skin of the animal, as well as areas of swelling at the injection site. Such phenomena do not require intervention. and pass through a few days on their own. Prolonged use of the drug and violation of dosages is strictly prohibited.

This may affect the functioning of the gastrointestinal tract and kidneys. When following the instructions for use and the correct calculation of the dosage, side effects and complications are not fixed.

If you have any health problems and a negative reaction of the animal to the drug, you must immediately stop taking Dithrim and contact a veterinarian.

Storage conditions and security measures

Ditrim dMust be stored using safety list B: The temperature should be between 5 and 25 ° C, the storage place should be dry and dark. The shelf life of the drug is 2 years with full compliance with the above conditions.

When using ditrim safety precautions must be observed when working with veterinary medicines, as well as the rules of personal hygiene. Ditrim low toxic drug helps to effectively fight infections of a bacterial nature, without causing their resistance.

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