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Antiprotozoan drug Pyrostop: instructions for use for dogs with therapeutic and prophylactic purposes

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In the article I will tell about the preparation for dogs pirostap. I will describe the instructions, the form of release and composition, give the mechanism of action of the drug. I'll tell you about the indications for use and dosage. Enumerate contraindications and side effects. I'll tell you if there are analogues, and give the cost.

Composition and release form

Pyrostop (or Piro-Stop) is a liquid solution intended to be injected subcutaneously or into a muscle. The main active ingredient is imidocarb dipropionate, each ml of the drug contains 120 mg of this substance. Also included are water for injection (1 ml), polyvinylpyrrolidone (10 mg), benzyl alcohol (9 mg) and propionic acid (30 mg).

Available in dark bottles, with a volume of 10, 20 or 100 ml, made of plastic or glass. Each vial is packaged in a proprietary box along with instructions.

Pyrostop is injected subcutaneously or into the muscle.

Mechanism of action and indications for use

Pyrostop shown to dogs with piroplasmosis (babesiosis). The causative agent is a unicellular parasite that destroys red blood cells. Carriers - ixodic ticks. The disease is accompanied by fever, darkening of the urine, a rapid deterioration of the general condition.

The main component of the agent is active against most species of babesia, theileria and anaplasma (only Babesia canis, B. gibsoni, Theileria annae are parasitic in the body of dogs). The substance prevents the ingestion of Babesia or Theileria Inositol, which is vital for the microorganism.

Side effects and contraindications

Side effects may occur with individual hypersensitivity:

Of the side effects may be shortness of breath, lacrimation, etc.

  • excessive drooling,
  • heart rhythm disorder
  • dyspnea,
  • muscle tremor
  • frequent urination,
  • lacrimation
  • soreness or swelling at the injection site.

In this case, hepatoprotectors are connected to the treatment in order to maintain liver function, intravenous fluids of electrolytes and symptomatic therapy.

Contraindications include individual hypersensitivity to the components. If the dog has been vaccinated against anaplasmosis or babesiosis, it is prohibited to use pyrostop within 4 weeks after the introduction of the vaccine. Also, the drug is not combined with organophosphate and organochlorine preparations.

Storage rules

The drug is stored strictly separate from food. It is also necessary to ensure that it is isolated from animals and small children. Do not allow direct sunlight on the bottle.

Shelf life under all conditions - up to 2 years at temperatures from +2 to +25 degrees. Once opened, the medicine can be used for 28 days, then it must be disposed of.

Cost and analogues

There are two groups of analogues. The composition of some includes imidocarb, it is more modern medicines that are more easily tolerated by pets. Preparations of the second group contain diaminazene aceturate. These drugs are more toxic, because Arsenic is present in their composition, so at the slightest overdose the animal can get severely poisoned.

The first group (imidocarb) include:

  • Imidosan. Effective with piroplasmosis (babesiosis), anaplasmosis and mixed invasions. Dosage for dogs - 0.05 ml per kilogram of weight, administered subcutaneously. The therapeutic effect lasts up to 3 weeks.
  • Fortikarb. Designed to treat piroplasmosis. Injected into the muscle or subcutaneously at a dosage of 4 mg per kilogram of weight. The drug protects the dog from babeziy for 15-30 days.
  • Corbezia. It is used to treat babesiosis (piroplasmosis) dogs. The tool is injected into the muscle or subcutaneously, twice, with a break of 2 weeks. Dosage - 6.6 mg per kilogram.
Choosing an analogue, it is worth paying attention to the composition, since arsenic is present in many preparations

The second group (diminazena aceturate) includes:

  • Azidine. Yellow powder, which is dissolved in water for injection and injected once intramuscularly or subcutaneously. Therapeutic dosage is 0.0035 g per kilogram, the prophylactic dose is 0.0015-0.002 g per kg.
  • Diamidine. Pinkish powder. Dosage - 2 mg per kg. Pre-drug is dissolved in the right amount of water for injection. Inject the drug into the muscle or subcutaneously, once.
  • Pirosan. Powder yellow. Before administration, it is dissolved in water for injection (0.5 g per 5.5 ml or 2.36 g per 25 ml). Dosage for dogs - 1 ml per 10 kg.
  • Veriben. Yellow powder, well soluble in water for injection (2.36 g per 25 ml). Dosage for dogs - 1 ml of solution per 10 kg of body weight. Enter once in the muscle or subcutaneously.

Any drugs are strictly contraindicated to enter their own. The dosage is selected strictly by weight. After the administration of the medicine, the animal must be observed by a veterinarian, who in case of complications will quickly provide him with first aid.

General information about the drug

When detecting blood-parasitic infections, it is important to destroy dangerous pathogens as soon as possible. In the absence of timely treatment, babesia and other microorganisms penetrate with a blood flow to the heart, respiratory tract, liver, kidneys, and severe lesions develop, up to and including death.

The preparation Piro-Stop on the basis of imidocarb dipropionate quickly and effectively acts in the body of dogs of small breeds. The antiprotozoal agent has a positive effect on the dynamics of therapy for babesiosis (piroplasmosis), anaplasmosis, nuttalliosis, and mixed infections.

The solution for injection is also prescribed to dogs of medium and large breeds.

Release form, composition

Imidocarba dipropionate is the active ingredient of the drug solution. The active ingredient exhibits a pronounced antiprotozoal effect. The active component corresponds to the imidazalin group.

Pharmacy chains receive antiprotozoan drug Piro-Stop in dark glass bottles. Each tank contains 10 ml of solution for injection.

Pyrostop and Piro-Stop - the same drug. In different sources you can find both names. Some authors indicate the first option, but the correct form: Pyro-Stop.

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Action on the dog's body

After the injection, imidocarb dipropionate is rapidly absorbed, the maximum concentration is noted in the blood after 18-24 hours. The positive point: a therapeutic dose of imidocarb, destructive for parasites, persists in the dog's body for another 1–1.5 months. The accumulation of the drug occurs in the kidneys of the liver, the remnants are excreted in the urine.

The mechanism of antiprotozoal effects: suppression of access to babesies, nuttalias, other parasites of the vitamin-like substance Inositol, without which blood parasites cannot exist. Also, the active component disrupts the synthesis of polyamines, leads to disruption of metabolic processes in blood parasites, which causes the death of microorganisms.

The drug is detrimental for various blood parasites:

  • Babesia (several species).
  • Anaplasma (2 species).
  • Francaiella colchica.
  • Ehrlichia canis.
  • Theileria orientalis (several varieties).
  • Nuttallia equi.

Pyro-Stop injection for injections is a tool with moderate danger to the organism of domestic animals. When complying with the dosage and regimen of application, the mutagenic, embryotoxic effect is practically not manifested. In the injection zone, irritation is rare.

Indications for use

Antiprotozoal drug is prescribed for the detection of blood parasites, the development of:

  • piroplasmosis,
  • Ehrlichiosis,
  • anaplasmosis,
  • nutllioza,
  • theileriosis
  • mixed types of blood infections.

Antiprotozoal medicine Pyro-Stop is effective as part of a combination therapy not only in dogs, but also in horses, cattle, sheep, mules, and donkeys.

Contraindications

The preparation of Piro-Stop on the basis of imidocarb dipropionate is not used for individual sensitivity of the animal to the active substance. With a tendency to allergic reactions to drugs, it is imperative to monitor the condition of the animal after the administration of an antiprotozoal agent. When a negative reaction is prescribed antihistamine drug.

Instruction

One of the advantages of the antiprotozoal drug Pyrostop is its high efficacy when administered once, twice or four times. It is enough for dogs to make one shot. Active action and concentration sufficient for the death of blood parasites persists in the body of sick animals for 4 to 6 weeks.

Injections are performed by a veterinarian after examining the test data to confirm the development of parasitic blood diseases. Be sure to follow the rules of sterility. Before the introduction of the solution, it is necessary to take into account contraindications, choose the optimal amount of funds, taking into account the individual characteristics of the dog and the weight of the animal.

How and where to prick

With the introduction of antiprotozoal solution possible pain in the animal. For this reason, small dogs, veterinarians prescribe not more than 2.5 ml of the drug in one place, the next batch (if necessary) is injected into another area.

Injection is performed subcutaneously. Be sure to treat the skin with a disinfectant composition. The injection should be done only by a veterinarian, Independent execution of the procedure can lead to side effects.

How often do you need injections

The drug Piro-Stop is prescribed for the treatment and prevention of parasitic blood infections. Depending on the purpose, select the optimal dosage and frequency of administration of the drug solution.

In order to prevent parasitic blood infections and to treat dangerous pathologies against the background of the penetration of dangerous pathogens, dogs are prescribed a single administration of an antiprotozoal.

Possible side effects and what to do when they appear

At individual sensitivity in dogs of small breeds, negative manifestations are possible:

  • bradycardia,
  • swelling and pain in the injection area (rarely occurs, disappears after one to two days),
  • enhanced saliva secretion
  • anorexia,
  • respiratory failure.

If side effects occur, as directed by the veterinarian, the animal receives atropine sulfate 1% subcutaneously, drugs to eliminate negative symptoms and medicinal names to reduce body sensitization. Be sure to monitor the dog after the injection for 15-30 minutes to study the reaction to the drug.

After the introduction of antiprotozoal drugs, with a high degree of infection, the massive death of blood parasites provokes the development of intoxication and destruction of red blood cells. As prescribed by the veterinarian, a dog receives sorbents, other drugs to eliminate the effects of the toxic effects of microorganisms.

special instructions

It is important to know the nuances of using Piro-Stop solution:

  • it is impossible to administer a drug to kill blood parasites, if less than 4 weeks ago, anaplasmosis or piroplasmosis was vaccinated,
  • do not administer medication for the prevention of a weakened animal,
  • lack of treatment of parasitic blood infections during pregnancy inevitably leads to the death of the animal. For this reason, prescribe medication Pyro-Stop and pregnant bitches. According to research data, imidocarb dipropionate practically does not give a negative effect on puppies in the womb,
  • It is important to ensure that the drug is used properly, strictly for injection. Do not use inside. If Piro-Stop medication gets on the mucous membranes, eyes, mouth, rinse the problem area with plenty of water, if an antiprotozoal solution is swallowed, it is urgent to take the animal to the veterinary clinic,
  • Piro-Stop and preparations that suppress the production of the cholinesterase enzyme cannot be used simultaneously.

Cost and storage of the drug

An effective antiprotozoal agent is produced by the Russian company Api-San. The price of 1 bottle is about 500 rubles.

For storage allocate a dry, protected from light, a place where there is no access for children and pets. The optimum temperature for preserving the properties of an antiprotozoal drug is from +2 C to +25 C. Do not freeze the solution for injection.

The shelf life of the funds Piro-Stop - 24 months. The opened bottle is stored in a cool place for no more than 28 days.

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Berenil and Azidine are powders with a similar, antiprotozoal effect. Drugs need to be diluted before the injection, which creates inconvenience. According to many breeders and veterinarians, pyrostop - more effectively and less often leads to complications after application. It is easier to adhere to the optimal dosage than when using Azidine and Berenil.

Veterinarians and dog owners positively evaluate the effect of Piro-Stop. If the requirements of the instructions are observed, negative reactions to imidocarb dipropionate rarely occur, the swelling in the injection zone quickly disappears. Compared with analogues that need to be diluted before use, Pirotostop is more convenient to use, less likely to cause similar effects.

Pyro-stop for dogs instructions for use

As stated above, the pyro-stop for dogs is injected subcutaneously or intramuscularly. Therapeutic (therapeutic) concentration in the blood of an animal is reached only after 18-24 hours. The drug is stored in the blood for one and a half to two months, which helps not only to destroy all blood parasites, but also to create a kind of “immunity”. If during this period the dog is bitten again by a tick, then the imidocarb circulating in the blood will protect the animal. The active ingredient all this time will be stored in the kidneys and liver.

Despite such a long cumulation (accumulation), with proper use and the absence of an allergic reaction to individual components, no side effects are observed. No danger to pregnant females. However, there are some nuances to keep in mind when using Pyro-feet for dogs:

  • The first 15 minutes after the administration of the drug must sit in the clinic. This is necessary in order to ensure that the dog has not developed anaphylactic shock (allergy) after drug administration. If the veterinarian notice the symptoms of allergy, then immediately introduced drugs that will relieve the attack (most often atropine 1%).
  • In order to avoid problems in the next day, it is necessary to introduce along with Pyro-stop and an antihistamine (for example, suprastin).
  • After 2 days, you need to visit the veterinary clinic again. First, the veterinarian will examine the pet: has he developed any complications? Secondly, you need to re-donate blood. If piroplasma is again detected in the smear, then repeated injection of Pyro-stop in the same dosage is required (no need to increase it).
  • If you have a large dog, then it is recommended to inject in one place not more than 2.5 ml, since the injection is very painful.

Now about the dosage. The dose of pyro-foot for dogs is 0.25-0.5 ml for every 10 kilo of weight. If you have to repeat the administration of the drug in a few days, then you must enter it in another place (on the other hand).

The price of Pyro-stop for dogs

The drug is produced in glass bottles of dark (brown) glass of 100 ml and in small ampoules of 10 ml and 20 ml. If you need to enter the dog once, then it is better to take a small ampoule, since after opening a large bottle must be split within 28 days. Vials of 100 ml are most often purchased by veterinarians at clinics, since they can use it before the expiration date. The unopened bottle can be stored for 2 years from the date of production.

The price for 10 ml varies depending on the margin of the veterinary pharmacy. On average, the cost of 520 rubles.

Reviews of pyro-stop for dogs

Alexander:

I decided to take the dog with me on nature. Only at home I noticed that there were ticks on it. Immediately went to the veterinary clinic. They dragged the bloodsuckers, treated the place of bites. But the vet advised for the prevention of stabbing the drug - Pyro-stop for dogs. He explained what would happen if the animal had piroplasmosis. Of course, I decided not to risk it. The injection is very painful, the dog screamed. The vet said to observe the well-being and behavior of the animal. A week later came to the inspection. There were no signs of the disease. The blood test is perfect. Now, before going for a walk, I use a spray and a tick collar, and upon returning home I carefully inspect the dog.

Valeria:

I noticed how the behavior of the newfoundler changed: it became weak, vomiting began, the body temperature rose, the appetite almost disappeared. But most frightened blood in the urine. Тут же вызвала ветеринара на дом. Он внимательно осмотрел Лайлу и обнаружил на ней напившихся крови клещей. Из-за густой шерсти не заметила их сама. По явным симптомам врач предположил, что у животного пироплазмоз. Сразу же ввел пиро-стоп для собак, поставил капельницу. Еще пару дней приезжал и капал Лайлу.Ticks took with him, said that they were found parasites. I believe that only thanks to Piro-stop and the quick, competent actions of the doctor was it possible to save my pet.

Daria:

Not saved us collar. I found ticks on my lab. I read articles about piroplasmosis more than once, so I did not wait for the symptoms. Immediately went to our "family" vet, explained the situation. Ticks removed, given to the laboratory. The result was told quickly: one of the ticks was a carrier. It became scary for her darling, but the doctor reassured that there is a wonderful drug that helps to destroy these parasites and protect the dog for another couple of months. Injected Pyro-stop for dogs. On this day, the dog was not very good, the injection site was slightly swollen. But the vet said that it was not a problem, but if the condition did not improve in the morning, I would have to put the dog in the hospital. Fortunately, after the night everything went away. No more ailments, and there were no symptoms of piroplasmosis. A great preparation, really magical. If he was not there, I would have lost my friend. But we have replaced the flea and tick protection products with stronger and more expensive ones.

Piro-stop (Piro-Stop) for dogs - indications for use

Dog Pyrostop is an injection solution for blood diseases. The main active ingredient is imidocarb dipropionate. The drug is available in single-use vials. After opening, the Pyro-Stop is stored for no more than 30 days, in a closed package no longer than 2 years.

The drug should be stored in a dark, cool place. Under improper storage conditions or expiration of the drug is strictly prohibited to use. Violation of this instruction leads to a sharp deterioration in the condition of the animal.

Is Pyro-stop safe for treating piroplasmosis in dogs?

If you do not delve into the parasitology, to understand the mechanism of action of the drug simply by the following example. Every parasite needs a favorable environment and nutrition. Parasites that live in the blood need a special substance - inositol. Pyro-stop suppresses the production of inositol, which kills the parasites.

There is a second side to the coin. Pyro-stop is effective, but dangerous for the dog if it is not sick! After the injection, the maximum concentration of the substance is injected for 24 hours and lasts up to 6 weeks. The active ingredient accumulates in the kidneys and liver, which provides serious support to the body if it is attacked by parasites.

Dogs pyro-stop is a complex drug used to treat:

  • Babesiosis (piroplasmosis) is a dangerous, flying blood disorder that often affects dogs. Carrier - grazing mite.
  • Franciaellosis is a blood disease of cattle.
  • Nutritionallia is a disease of the blood of horses.
  • Teileriosis is a parasitic disease of the blood of cattle.
  • Anaplasmosis (infectious thrombocytopenia) is a severe disease of the blood of animals, including dogs.
  • Ehrlichiosis is a disease of the blood of mammals, including dogs. Carrier - mite.

Important! Piro-stop injections are very painful! If you need to enter a large dose at once, make several injections. If necessary, to reduce pain, the injection sites are anesthetized topically.

Pyro-stop for the prevention of piroplasmosis in dogs

There are different opinions about the use of Piro-stop for prophylaxis and controversy is very frequent. In the instructions of the drug is written that it is not recommended to use more than 1 time per year. The fact of the development of immunity is not proven, as well as the fact that this is possible in principle.

Learning, having applied Pyro-stop for prophylaxis, you do not get guarantees that the dog will not get sick. If you get sick, the drug will have to prick again, and this is a significant "blow" to the liver. The opinions of veterinarians in this matter are very different. Most experts do not recommend stabbing Piro-stop without first making a diagnosis.

Can a Pyro-Stop be used to treat a pregnant or lactating dog?

Can a Pyro-Stop be used to treat a pregnant or lactating dog? A screaming question that raised a wave of heated discussions. On the one hand, if a future or young mother becomes ill with pyroplasmosis, she will die. On the other hand, if there is a chance that the diagnosis is set incorrectly there is a chance of a pregnancy failure. If a nursing dog is sick, it is treated with Pyro-foot after weaning puppies.

The flip side of the coin is the experience of owners who have fallen into a hopeless situation. Veterinarians managed to save pregnant dogs without harming the offspring even at the severe stage of piroplasmosis.

The problem is that the instruction is silent whether it is possible to use Pyro-stop during pregnancy and feeding, so the owners and veterinarians act at their own peril and risk.

Application and dosage of Pyro-foot

Dosage of Pyro-stop in treating dogs for pyroplasmosis is the same: 0.25–0.5 ml of the drug per 10 kg of body weight. It is important to understand that even in a small volume the injection causes severe pain to the animal. Note that after the introduction of the drug is possible severe intoxication.

Usually, before the injection, blood is taken from the dog and a rapid test is performed. If the diagnosis is confirmed, Pyro-stop is injected in the clinic. With the introduction of the drug is extremely important to follow the rules of septic tanks and antiseptics.

Where and how to prick Pyro-stop

Where to prick Piro-stop to minimize pain syndrome? If the volume of the injection exceeds 2.5 cubes, the drug is drawn into several syringes. According to the instructions, Piro-stop can be prickled in the muscle (thigh) or subcutaneously (in the withers). When splitting the dose of the injection, the drug is administered in several places, alternately, with a short break.

Immediately after the injection, within 15 minutes, a close observation is established for the dog. During the first 15 minutes there is a risk of a violent allergic reaction. If the dog suffers from allergies, without waiting for the disturbing symptoms, the dog is given an antihistamine.

What is fraught with overdose

An overdose of Pyro-foot is likely to kill the dog. The problem is that the liver does not cope with the load anyway, and when Pyro-stop is injected, there is a massive death of damaged red blood cells. The dog sharply decreases hemoglobin, which is fraught with ataxia and slower metabolic processes.

It turns out the next "fork" - intoxication increases dramatically, and the process of blood purification slows down critically. The situation can be corrected in the clinic by cleansing the blood and infusing a large number of buffer solutions.

It is important to understand that after an overdose, the dog will need long-term restorative therapy for the liver.

Piro stop stop shot - what to do?

A bump may form at the injection site. There are two main reasons: too much of the administered drug or an individual reaction. In both cases, the situation is observed and symptomatic care - compresses, ointments. If the bump does not cause the dog inconvenience, most likely, it will pass without intervention in a period of up to 48 hours.

In rare cases, the bumps become inflamed. The main reason - violation of the rules of septic tanks. With localized inflammation, the situation is corrected with compresses with novocaine and dimexide. If there is a threat of purulent inflammation, antibiotics and anti-inflammatory agents are injected into compresses. When purulent inflammation of the lump open or provoke the opening of the fistula.

Analogs and the relevance of their use

Are there any Piro-foot analogues? - Yes! Is it reasonable to use them? - Not! For reference, the Piro-stop analogues are Berenil, Azidine, and Veriben. The drugs are very strong and dangerous. Even if you do not go into details, think for yourself, why use Piro-stop for dogs to treat blood diseases even in cattle? The answer is obvious - it is not so dangerous.

Before using analogues that are intended for farm animals, select the control group and inject the drug. If animals survive, vaccinate the rest of the herd. In addition, analogues, like Piro-stop, conflict with vaccines, make it impossible to use milk and meat for food.

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